منابع مشابه
Cyclosporin neurotoxicity after chemotherapy.
Contributors: DEW designed the audit, collected and analysed the data, and participated in writing the paper with EHB. EHB provided DEW with the list of subjects to be investigated, discussed core ideas, and participated in writing the paper; she maintains the database of mothers who are hepatitis B positive and advises on appropriate immunisations. EHB will act as guarantor for the paper. Comp...
متن کاملCyclosporin neurotoxicity in cardiac transplant recipients.
Cyclosporin toxicity may produce a wide range of neurological disorders. We report three patients whose neurological problems developed while taking cyclosporin following cardiac transplantation, but resolved rapidly when the drug was discontinued. In two cases, MRI revealed abnormalities which disappeared with clinical recovery. Blood cyclosporin concentrations were not markedly increased, and...
متن کاملMR imaging of reversible cyclosporin A-induced neurotoxicity.
Neurotoxicity is a recognized complication of cyclosporin A (CsA) therapy in patients undergoing organ transplantation. It is most commonly manifested by fever, seizures, and altered mental status. Cortical blindness and speech and motor disturbances can also occur. Changes seen in cerebral white matter on imaging studies are nonenhancing areas of hypoattenuation on CT and T2 prolongation on MR...
متن کاملEtiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity.
BACKGROUND AND PURPOSE The etiology of the neurotoxicity associated with cyclosporin-A (CsA) and FK-506 treatment is not fully understood. At our institution, we noticed a distinct, abrupt change in the imaging characteristics of CsA and FK-506 neurotoxicity, which consisted of a shift in lesion morphology from a white matter abnormality to a mixed cortical and white matter pattern. The purpose...
متن کاملCyclosporin A and Cyclosporin SDZ
Recent studies have shown that cyclosporin A (CsA) may affect ricin A-chain immunotoxin (RTA-IT) therapy. In this study, we evaluated the ability of CsA and its nonirnmunosuppressive analog. SDZ PSC 833, to enhance anti-CD5 T l O l RTA-ITS in vitro. Both 4 pmol/L CsA and 4 pmol/L SDZ PSC 833 significantly and specifically enhanced the cytotoxic activity of T101 RTA-IT on the human lymphoblastic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2003
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2003.04524.x